Kathy Lee
Visiting Assistant Professor, Department of Biology
Telephone: 216-397-4483
Email:klee@jcu.edu
Office: Dolan W 209
B.S. in Biology, University of Akron, Akron, OH
Ph.D. in Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH
Post-doctoral research in steroid hormone receptors at Cornell University, Ithaca, NY
Post-doctoral research in psoriasis and anti-microbial skin proteins at Case Western Reserve University, Cleveland, OH
Research Interests
My research interests are focused towards gene regulation and how changes in protein expression affect cellular behavior. Changes in gene expression can occur for a variety of reasons in eukaryotic organisms including, but not limited to, organismal development, disease, and environmental influences. In order to understand how these processes affect the organism as a whole, it is important to first comprehend the changes that are occurring on the cellular level. While my earlier research was directed towards transcriptional regulation of specific genes, I have also completed research on a more physiological level during my investigation of proteins that influence cell survival.
Recent Courses
BL 109 – Environmental Science
BL 109L – Environmental Science Lab
BL 155 – Principles of Biology I
BL 156 – Principles of Biology II
BL 213 – Genetics
BL 410 – Infection and Immunity
Selected Publications
Balasubramanian S, Lee K, Adhikary G, Gopalakrishnan R, Rorke EA, Eckert RL.: The Bmi-1 polycomb group gene in skin cancer: regulation of function by (-)-epigallocatechin-3-gallate. Nutr Rev. 66, S65-8, 2008.
Lee KC, Adhikary G, Balasubramanian S, Gopalakrishnan R, McCormick T, Dimri GP, Eckert RL, and Rorke EA.: Expression of Bmi-1 in epidermis enhances cell survival by altering cell cycle regulatory protein expression and inhibiting apoptosis. J Invest Dermatol. 128, 9-17, 2008.
Lee, K.C. and Eckert, R.L.: S100A7 - an Antibacterial Role in Wound Healing. J Invest Dermatol 127, 945-57, 2007.
Eckert, R.L. and Lee, K.C.: S100A7 (Psoriasin): a Story of Mice and Men. J Invest Dermatol 126, 1442-1444, 2006.
Eckert, R.L., Broome, A.M., Ruse, M., Robinson, N., Ryan, D., Lee, K.C.: S100 Proteins in the Epidermis. J Invest Dermatol 123, 23-33, 2004.
Acevedo, M.L., Lee, K.C., Stender, J.D., Katzenellenbogen, B.S., Kraus, W.L.: Selective Recognition of Distinct Classes of Coactivators by a Ligand-Inducible Activation Domain. Mol. Cell 13, 725-738, 2004.
Lee, K.C., Li, J., Cole, P.A., Wong, J.: Transcriptional Activation by Thyroid Hormone Receptor Beta Involves Chromatin Remodeling, Histone Acetylation, and Synergistic Stimulation by p300 and SRC Coactivators. Mol Endo 17, 908-922, 2003.
Links
|
