Favorite Datasets from Early Phases of Drug Research

Exploratory Teratology Study in Rats

Part 2 - Table 1


Forty pregnant female rats were assigned randomly to one of four treatments (10 rats/treatment) including a Vehicle Control and graded oral doses (50, 100, 200 mg/kg) of an investigational compound. Dosing was performed once daily on Days 16 through 19 of gestation. On Day 20, the animals were sacrificed. The anogenital distance and sex of each fetus was recorded. Average anogenital distances for each sex in a litter are shown in Table 1.

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Part 2 - Table 1

Exploratory Teratology Study in Rats

Average Anogenital Distance (mm) Per Litter

Dose Litter
(mg/kg) Sex 1 2 3 4 5 6 7 8 9 10
0 M 2.66 2.66 2.34 2.34 2.68 2.44 2.43 2.79 2.80 2.61
0 F 1.11 1.18 1.13 1.09 1.26 1.10 1.15 1.27 1.21 1.17
50 M 1.76 1.56 2.28 1.74 1.95 1.82 1.91 1.83 2.24 1.91
50 F 0.98 1.06 1.40 1.01 1.14 1.02 1.13 1.20 1.27 1.14
100 M 1.58 1.56 1.48 1.55 1.51 1.92 1.48 1.48 1.72 1.52
100 F 1.11 1.10 1.18 1.12 1.13 1.32 1.20 1.05 1.28 1.23
200 M 1.28 1.30 1.24 1.30 1.26 1.42 1.20 1.20 1.39 (a)
200 F 1.01 1.08 1.01 1.06 1.12 1.38 1.11 1.15 1.27 (a)

(a) All fetuses found dead


Source:

Bradstreet, T.E. (1992) "Favorite Data Sets from Early Phases of Drug Research - Part 2." Proceedings of the Section on Statistical Education of the American Statistical Association.

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Last modified July 27, 2010 - THS