Favorite Datasets from Early (and Late) Phases of Drug Research

Cost and Esophageal Healing

Part 4 - Table 7


One hundred and eighty-four patients were allocated to one of two treatments (Treat) for severe erosive esophagitis. The primary efficacy endpoint was the healing of all erosions as determined by endoscopy after four and eight weeks of therapy. Patients who healed at four weeks left the study and were assumed to still be healed at week 8. Cost data were also collected with respect to study drug and concomitant antacids as well as all non-protocol driven medical costs (i.e., physician visits, emergency room visits, treatment of adverse effects, procedures, etc.) from the prospective of a third party payor. Total costs are tabulated.

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Part 4 - Table 7
Cost and Esophageal Healing
Treat BsSev (a) Healed? Total Cost (b)
12 Yes 100 1219 92 219 96 187 95 99 99 95 96 77
81 327 99 106 100 100 95 99 165 134 96 124
100 95 99 106 1681 103 95 95 106 99
No 247 92 197 197 60 199 106
3 Yes 92 99 207 194 99 201 104 109 189 95 96 268
107 102 103 82 95 187 95 106 93 107 210 197
106 99 74 81 100 88 103 95
No 248 197 204 18 106 516
4 Yes 92 208 103 256 106 99 99 99 194
No 201 536 211 200
22 Yes 87 132 222 217 171 98 92 192 105 79 106 196
95 231 108 94 96 96 103 190 94 208 96 75
201 33 110
No 3 52 190 202 104 142 7 216 240 272 97 194
197 203 66 267
3 Yes 97 97 319 182 94 145 96 79 91 176 211 198
99 91
No 183 198 195 175 194 203 114 97 143 204 74 207
189 11 189 195 388 206 199 420 206 207 189 166
4 Yes 90
No 208 276 296 327 124 202 210 101 199 47

(a) A higher rating indicates greater severity of disease.

(b) Each value represents an individual patient. Values were rounded to nearest dollar (1992 U.S.).


Source:

Bradstreet, T.E. and Liss, C.L. (1995) "Favorite Data Sets from Early (and Late) Phases of Drug Research - Part 4." Proceedings of the Section on Statistical Education of the American Statistical Association.

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Last modified July 27, 2010 - THS