Plasma Total Drug  Plasma Unbound Drug
           Day 1     Day 7    Day 1     Day 7
Sub Sex AUC24 AUCinf AUC24 AUC24 AUCinf AUC24
 1  M   606.1 627.4  657.2 42.9  45.6   46.8
 2  M   659.2 684.3  597.5 45.5  48.5   40.4
 3  M   808.0 886.5  743.8 58.5  63.9   62.9
 4  M   905.8 995.3  771.2 59.2  64.1   47.5
 5  M   836.7 884.5  777.0 56.0  58.1   52.1
 6  M   697.2 733.5  688.4 38.4  42.0   37.7
 7  M   709.0 749.6  702.6 46.3  50.3   49.0
 8  F   702.9 739.4  592.8 52.2  54.2   43.4
 9  F   745.5 770.3  612.8 60.0  62.8   46.3
10  F   695.3 709.2  697.6 47.7  49.3   42.2
11  F   825.3 853.8  714.6 62.7  65.7   58.5
12  F   731.8 743.2  663.8 53.3  54.7   42.3
13  F   729.0 751.3  626.5 52.4  54.3   43.7
14  F   792.9 812.9  700.4 58.9  61.6   51.5