Plasma Unbounded Drug Plasma Total Drug AUC C12 Ceoi AUC C12 Ceoi Sub Age Sex 1 g 2 g 1 g 2 g 1 g 2 g 1 g 2 g 1 g 2 g 1 g 2 g 1 E M 45.6 95.6 0.70 1.21 15.0 48.6 627.4 1083.2 13.6 22.1 143.7 257.9 2 E M 48.5 105.6 0.89 1.52 17.0 44.8 684.3 1102.3 15.3 22.4 151.8 254.4 3 E M 63.9 124.2 1.11 2.41 11.1 42.9 886.5 1493.1 24.4 38.0 121.1 248.7 4 E M 64.1 126.7 1.46 2.24 11.4 42.5 995.3 1373.7 28.3 34.6 125.0 251.5 5 E M 58.1 124.0 1.08 1.71 18.9 47.2 884.5 1294.7 22.9 30.4 168.5 260.1 6 E M 42.0 105.0 0.84 1.67 14.0 48.7 733.5 1110.6 18.0 26.4 155.3 241.2 7 E M 50.3 106.7 1.00 1.89 15.0 43.6 749.6 1301.1 17.9 31.5 146.8 254.6 8 E F 54.2 107.1 1.15 1.59 16.0 46.3 739.4 1229.9 17.9 28.7 145.7 262.9 9 E F 62.8 132.2 0.97 1.46 23.5 59.0 770.3 1183.7 17.0 24.8 167.2 295.9 10 E F 49.3 123.3 0.90 1.29 19.6 64.1 709.2 1195.6 15.2 23.2 176.0 338.1 11 E F 65.7 123.4 1.01 1.65 25.7 57.0 853.8 1180.3 19.2 24.0 185.1 265.2 12 E F 54.7 133.2 0.68 0.97 23.7 79.5 743.2 1088.0 13.6 18.1 185.8 308.6 13 E F 54.3 137.5 0.76 1.47 20.7 88.3 751.3 1283.7 16.0 26.3 174.6 316.9 14 E F 61.6 151.6 1.08 1.56 22.3 96.9 812.9 1241.1 16.9 23.1 193.6 335.2 1 Y M 29.9 61.4 0.49 0.77 9.7 24.8 604.6 868.1 11.6 15.2 139.6 229.2 2 Y M 29.1 52.6 0.41 0.65 10.2 25.0 549.7 901.7 9.7 17.1 154.4 234.5 3 Y M 23.9 47.1 0.31 0.54 8.3 23.8 475.5 792.4 8.4 13.6 123.3 224.1 4 Y M 28.0 80.5 0.48 1.14 8.4 30.0 514.3 1231.4 11.2 23.6 115.1 312.1 5 Y M 46.8 84.7 0.83 1.17 13.6 37.7 697.3 1105.7 14.5 23.4 151.0 263.6 6 Y M 32.2 72.6 0.50 0.84 9.9 34.8 498.0 912.5 8.8 17.1 132.9 245.3 7 Y M 34.5 84.3 0.31 0.47 17.9 63.5 689.3 1064.3 9.5 13.2 178.5 363.6 8 Y M 28.2 68.9 0.43 0.73 10.8 35.4 572.8 1014.0 8.8 16.8 158.7 273.3 9 Y F 40.0 81.4 0.60 0.86 13.2 47.1 657.9 1066.4 13.9 18.5 143.6 284.5 10 Y F 35.3 89.1 0.38 0.71 14.7 57.6 587.1 1006.8 9.7 16.4 164.2 280.0 11 Y F 32.1 77.0 0.30 0.74 10.9 34.7 587.9 1130.0 10.7 18.1 153.7 255.8 12 Y F 32.2 89.2 0.17 0.75 15.0 46.8 508.5 1105.2 5.2 16.3 163.0 290.1 13 Y F 33.4 82.4 0.35 0.65 16.6 60.7 629.9 1030.7 8.1 14.0 199.4 350.5 14 Y F 38.8 92.3 0.46 0.66 16.3 70.7 530.1 992.6 7.9 13.9 152.3 311.1 15 Y F 31.6 85.7 0.30 0.59 14.4 50.1 534.8 1102.5 7.8 16.5 160.8 322.3 16 Y F 35.8 76.9 0.20 0.46 16.9 50.6 516.6 857.6 3.6 9.0 187.1 287.1