Favorite Datasets from Early (and Late) Phases of Drug Research

Developmental Signs Testing in Rat Pups

Part 5 - Table 1


In a reproduction study, dam rats were allocated randomly to treatment with either 0, 3.125, 6.25, or 12.5 mg/kg of an investigational compound. Treatment was initiated 15 days prior to cohabitation with similarly treated males, and continued through Day 20 of gestation. Two male and two female pups from each litter were tested in a battery of developmental signs procedures including auditory startle response. In each litter, for each sex separately, the number of pups responding positively out of the number of pups tested was recorded as 2/2, 1/2, or 0/2. The data in Table 1 represent the observed frequencies for auditory startle response in females.

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Part 5 - Table 1
Developmental Signs Testing In Rat Pups
Litter Counts
#Pups Auditory Startle Response
Responding/ in Females
#Pups Tested

0

3.125

6.25

12.5

Total
2/2 13 14 14 13 54
1/2 0 0 1 0 1
0/2 0 0 0 1 1
Total 13 14 15 14 56

Source

Bradstreet, T. E. and Short, T. H. (2001) "Favorite Data Sets from Early Phases of Drug Research - Part 5." Proceedings of the Section on Statistical Education of the American Statistical Association.

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Last modified September 4, 2011 - THS