Parent Compound (P) Metabolite (M) AUC Cmax AUC Cmax Sub Seq 1x40 4x10 1x40 4x10 1x40 4x10 1x40 4x10 1 4-Jan 925 1107 85.7 110.8 1325 1446 33.6 41.2 2 1-Apr 1125 1152 97.4 105.0 1677 1735 46.6 43.6 3 1-Apr 1952 1525 135.0 113.0 2810 2333 42.9 40.0 4 4-Jan 836 1144 69.1 94.7 1376 1624 33.3 36.0 5 4-Jan 1514 1164 111.0 88.6 2253 1757 43.2 39.6 6 1-Apr 1048 1167 72.6 79.1 1470 1681 33.8 31.6 7 1-Apr 1003 1271 80.0 94.8 1300 1594 28.3 32.0 8 4-Jan 574 636 55.0 73.7 854 915 28.6 29.5 9 1-Apr 2747 2834 176.0 176.0 3513 3797 49.6 54.9 10 4-Jan 726 828 55.9 72.0 1245 1239 25.1 27.6 11 4-Jan 1773 1399 137.0 119.0 2056 1785 43.3 37.8 12 1-Apr 1257 1520 99.8 112.0 1850 2059 35.2 38.4 13 1-Apr 1147 1119 81.7 91.7 1740 1721 31.6 36.0 14 4-Jan 673 825 51.8 60.0 1013 1195 20.3 20.9